Evidence map›Paper›PMID 42209689›Full record

ArticleScientific reports2026

Cortical thinning with increasing OSA severity stages in adult comorbid insomnia and sleep apnea and its relevance for respiration measures.

Liping Pan, Lifeng Hang, Hui Li, Yi Yin, Liming Li, Wenfeng Zhan, Yongli Li, Quanxin He, Jingping Yang, Huiyu Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liping Pan *The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Lifeng Hang *The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Hui Li *People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Yi YinThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Liming LiThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Wenfeng ZhanThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yongli LiDepartment of Health Management, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan, China.
Quanxin HeThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Jingping YangThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Huiyu ChenThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yuting WuThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Shujuan QiuThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Shumei LiThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. shumeili0412@qq.com.
Guihua JiangThe Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. jiang2002@163.com.

Funding

Lift Project Foundation of Guangdong Second Provincial General Hospital TJGC-2025003National Natural Science Foundation of China U1903120Natural Science Foundation of China 81901731Science and Technology Project in Guangzhou 2023A04J1849Science and Technology Project in Guangzhou 2025A03J4294
6 · The paper itself

Abstract

The study aimed to analyze the alterations of cortical thickness (CT) in comorbidity of insomnia and sleep apnea (COMISA) patients of varying severity and the relationships of these CT changes with clinical measures. The study included 34 COMISA patients and 24 healthy controls (HCs). The patients received structural MRI as well as measures associated with respiration, sleep, cognition, and mood, and were classified as mild and moderate (MC) or severe (SC) groups. The CT for COMISA was analyzed through surface-based morphometry (SBM). Voxel-wise differences in CT between two groups were analyzed. Individual CT maps of MC, SC, and HC groups were used in analysis of variance for investigating how COMISA severity at various stages affects CT. Partial correlation analysis was used for analyzing the relations between changes in CT and clinical measures. Reduced CT was located in four clusters, including left supramarginal gyrus, left precentral and postcentral gyri, right pericalcarine and lingual gyri, and right rostral and caudal middle frontal gyri in COMISA group. The CT of left supramarginal gyrus was found in MC group, whereas all four clusters in SC group Moreover, the partial correlation analysis results revealed that CT was significantly related to respiration measures (AHI and LSaO

Indexed as

Cerebral CortexCerebral Cortical ThinningSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersAdultCase-Control StudiesComorbidityFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRespirationSeverity of Illness IndexComorbid insomnia and sleep apneaCortical thicknessHypoxiaInsomnia disorderObstructive sleep apneaSupramarginal gyrus

Identifiers

PMID42209689
PMCPMC13448248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.