Evidence map›Paper›PMID 42209674›Full record

ArticleCommunications biology2026

Placebo analgesia persistence: evaluating behavioural stability in repeated trials.

Lewis S Crawford, Damien C Boorman, Ashleigh H Wake, Allan Peng, Rebecca V Robertson, James W M Kang, Furby Robson, Paul M Macey, Kevin A Keay, Luke A Henderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lewis S CrawfordSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0003-2231-5196
Damien C BoormanSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.
Ashleigh H WakeSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.ORCID 0009-0000-2674-4591
Allan PengSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.
Rebecca V RobertsonSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.ORCID 0009-0005-0795-1532
James W M KangSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0002-8517-5656
Furby RobsonSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.
Paul M MaceySchool of Nursing and Brain Research Institute, University of California, Los Angeles, CA, USA.ORCID 0000-0003-4093-7458
Kevin A KeaySchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia.ORCID 0000-0003-3934-4380
Luke A HendersonSchool of Medical Sciences (Neuroscience), University of Sydney, Camperdown, NSW, Australia. luke.henderson@sydney.edu.au.ORCID 0000-0002-1026-0151

Funding

Department of Health | National Health and Medical Research Council (NHMRC) 1130280
6 · The paper itself

Abstract

Placebo analgesia is widely believed to rely on psychological, genetic, and biological factors. Whilst these factors have been assessed in single expressions of this phenomenon, few have documented its consistency over time, limiting understanding of its stability, and by extension, consideration in non-experimental settings. Here we show in 30 control participants by combining magnetic resonance imaging and a longitudinal design spanning five sessions, the psychological and neural substrates underpinning Placebo Analgesia response consistency.

Indexed as

AnalgesiaPlacebo EffectAdultBrainFemaleHumansMagnetic Resonance ImagingMale

Identifiers

PMID42209674
PMCPMC13500666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.