Evidence map›Paper›PMID 42209516›Full record

ArticleNPJ Parkinson's disease2026

Superior dorsal nigral hyperintensity depiction at 7 T MRI using CLEAR-DESS improves diagnosis performance of Parkinson's disease.

Sai Li, Ruiting Chen, Qing Li, Yicheng Hsu, Jiaqi He, Yihang Su, Dongcui Wang, Hao Zhou, Weiwei Zhang, Li Meng and 9 more

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Sai Li *Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Ruiting Chen *Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Qing LiMR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China.
Yicheng HsuMR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China.
Jiaqi HeDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Yihang SuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Dongcui WangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Hao ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Weiwei ZhangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Li MengDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Shulin LiuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Jingyi TangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Chenyu LiDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Peng LeiDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Long QianMR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China.
Jianxun QuMR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China.
Wu XingDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Harrison X BaiDepartment of Radiology-Diagnostics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China. owenliao@csu.edu.cn.

Funding

National Natural Science Foundation of China U25A20137, 82471984, 82071894, and 91959117Science and Technology Program of Hunan Province 2020RC4007Scientific Research Program of FuRong Laboratory 2024PT5110
6 · The paper itself

Abstract

This study aimed to compare the qualitative and quantitative measurement of dorsal nigral hyperintensity (DNH) and its diagnostic efficacy for Parkinson's disease (PD) between 7 T MRI sequences: the combined liquid and blood vessel attenuation with refined double echo steady state (CLEAR-DESS) and susceptibility-weighted imaging (SWI). Following sequence simulation and optimization, a prospective study enrolled 33 PD patients and 52 healthy controls, all undergoing 7 T MRI with CLEAR-DESS and SWI. Four blinded observers qualitatively assessed image quality and DNH visibility, while two independent readers performed quantitative analyses of signal-to-noise (SNR) and contrast-to-noise ratios (CNR). Excellent inter-observer agreement was noted for both qualitative assessments. Diagnostic performance at the DNH level showed CLEAR-DESS (4 observers; AUC: 0.90-0.96; sensitivity: 85%-96%; specificity: 88%-94%) significantly outperformed SWI (4 observers; AUC: 0.73-0.85; sensitivity: 65%-70%; specificity: 74%-89%). Similarly, at the patient level, CLEAR-DESS (4 observers; AUC: 0.91-0.96; sensitivity: 91%-94%; specificity: 88%-100%) surpassed SWI (4 observers; AUC: 0.79-0.87; sensitivity: 80%-89%; specificity: 60%-79%). CLEAR-DESS also showed significantly better DNH visualization slices, SNR, and CNR than SWI (all p < 0.001). The 7T CLEAR-DESS sequence provides superior DNH visualization and PD diagnostic performance compared to SWI, indicating its potential as a preferred choice for DNH evaluation.

Identifiers

PMID42209516
PMCPMC13500533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.