Evidence map›Paper›PMID 42209469›Full record

ArticleBone research2026

A tissue engineering approach to regenerate the cranial suture skeletal stem cell niche with a multicompartment biomaterial scaffold.

W Benton Swanson, Lindsey Douglas, Seth M Woodbury, Jackson Albright, Haichun Pan, Maiko Omi-Sugihara, Miranda Eberle, Jake Herremans, Hwa Kyung Nam, Rafael Correia Cavalcante and 4 more

Abstract read
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In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

W Benton SwansonDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA. wbentons@umich.edu.ORCID 0000-0002-8074-7117
Lindsey DouglasDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Seth M WoodburyDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Jackson AlbrightDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Haichun PanDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Maiko Omi-SugiharaDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Miranda EberleDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Jake HerremansDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Hwa Kyung NamDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Rafael Correia CavalcanteDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Coral ChenDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Peter X MaDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0191-9487
Nan E HatchDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Yuji MishinaDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA. mishina@umich.edu.ORCID 0000-0002-6268-4204

Funding

Regenerating cranial suture (Jaylynn Jones)R01DE027662 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HATCH, NAN E, MA, PETER X · 2018 to 2022
$2.6M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
NCRR NIH HHS S10 RR026475NIAMS NIH HHS P30-AR069620U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) F30-DE029359U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE027662U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) T32-DE007057
6 · The paper itself

Abstract

Craniosynostosis is a debilitating congenital anomaly characterized by the premature fusion of cranial sutures in the skull, resulting from the abnormal fate specification of critical skeletal stem cells. This leads to disrupted craniofacial development and dysmorphology. As an alternative to invasive cranial vault remodeling surgery, we propose a tissue engineering approach to effectively restore the damaged or absent suture stem cell niche using a biomaterial capable of regioselective stem cell maintenance, marking a significant paradigm shift. By harnessing the role of biomaterial scaffold pore design to direct cell fate, we developed a "bone-suture-bone" design within a triphasic scaffold. We demonstrate that this unique scaffold design maintains stemness in a central region while promoting osteogenic differentiation in the surrounding areas, replicating the interfaces and function of the native suture. The scaffold's ability to reconstitute an engineered skeletal stem cell niche and facilitate the functional recovery of the craniosynostosis phenotype is validated in a caBmpr1a; Wnt1-Cre murine model of midline craniosynostosis, the most common nonsyndromic clinical presentation in humans. This work shows significant promise for improving patient outcomes through a rational tissue engineering strategy for reconstituting a native stem cell niche.

Indexed as

Biocompatible MaterialsBone RegenerationCranial SuturesStem Cell NicheTissue EngineeringTissue ScaffoldsAnimalsCell DifferentiationCraniosynostosesHumansMiceOsteogenesisBiocompatible Materials

Identifiers

PMID42209469
PMCPMC13219457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.