ArticleJournal of extracellular vesicles2026
Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy.
Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy.Journal of extracellular vesicles · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
mRNA-based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non-integrating expression of therapeutic proteins. However, effective and tumour-specific delivery remains a major barrier. In this study, we report a cell membrane vesicle (CMV)-based delivery platform for targeted mRNA therapy, employing engineered CMVs enriched with the surface molecule CD6 for the selective delivery of Il24 mRNA to CD166-overexpressing tumour cells. CMVs were derived from NIH-3T3 cells via cytochalasin B induction and genetically modified to express CD6, enabling biomimetic targeting through the CD6-CD166 axis. Il24 mRNA was loaded into CD6-CMVs through a digitonin-assisted permeabilisation strategy, achieving high encapsulation efficiency and sustained intracellular release. In vitro, CD6-CMVs facilitated enhanced uptake in CT26 cells, leading to elevated IL-24 expression, activation of apoptotic and autophagic pathways, and suppression of migration and invasion. In mouse colorectal cancer and squamous carcinoma models, CD6-CMVs/Il24 mRNA demonstrated effective tumour targeting, increased intratumoral IL-24 translation, and potent antitumor efficacy, with minimal off-target accumulation or systemic toxicity. Notably, this treatment promoted immune cell infiltration and reshaped the tumour microenvironment towards a pro-inflammatory state. This study presents a scalable, low-immunogenicity CMV platform capable of targeted mRNA delivery and cytokine expression, offering a promising strategy for precision immunotherapy for solid tumours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.