Evidence map›Paper›PMID 42209429›Full record

ArticleJournal of extracellular vesicles2026

CD133 Shapes Extracellular Vesicle Cargo and Angiogenic Function in Basal-Like Triple-Negative Breast Cancer.

Mireia Gomez-Duro, Ptissam Bergam, Sara Sanchez-Redondo, Florent Dingli, Alix Zhou, Alain Joliot, Mengliang Ye, Marta Hergueta-Redondo, Lucas Alves Tavares, Damarys Loew and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mireia Gomez-DuroStructure and Membrane Compartments, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0009-0000-5534-7878
Ptissam BergamStructure and Membrane Compartments, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0002-4909-121X
Sara Sanchez-RedondoMicroenvironment and Metastasis Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Florent DingliCurieCoreTech Mass Spectrometry Proteomics, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0002-7715-2446
Alix ZhouINSERM U932, Institut Curie Research Center, PSL Research university, Paris, France.
Alain JoliotINSERM U932, Institut Curie Research Center, PSL Research university, Paris, France.ORCID https://orcid.org/0000-0002-2215-1550
Mengliang YeTranslational Research Department, CNRS UMR144 Cell Biology and Cancer, Breast Cancer Biology Group, Institut Curie - PSL Research University, Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0002-1988-4358
Marta Hergueta-RedondoMicroenvironment and Metastasis Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Lucas Alves TavaresStructure and Membrane Compartments, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0001-7883-1443
Damarys LoewCurieCoreTech Mass Spectrometry Proteomics, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0002-9111-8842
Thierry DuboisTranslational Research Department, CNRS UMR144 Cell Biology and Cancer, Breast Cancer Biology Group, Institut Curie - PSL Research University, Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0001-9621-3016
Lorena Martin-JaularCurieCoreTech Mass Spectrometry Proteomics, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0002-1511-8576
Hector PeinadoMicroenvironment and Metastasis Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.ORCID https://orcid.org/0000-0002-4256-3413
Graça RaposoStructure and Membrane Compartments, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0001-9590-1298
Gisela D'AngeloStructure and Membrane Compartments, Institut Curie, PSL Research University, Paris, France.ORCID https://orcid.org/0000-0003-3150-2241

Funding

Centre National de la Recherche Scientifique (CNRS)European UnionEuropean Union's Horizon 2020 research and innovation programmeEVCA Twining project 101079264Fondation ARC pour la Recherche sur le Cancer PJA2024070008456Institut CurieInstitut Curie EuReCa PhD Programme 847718La Ligue Contre le Cancer RS25/75-81Marie Skłodowska-Curie 847718
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are central mediators of tumour-stroma communication, yet the mechanisms governing their biogenesis and functional cargo remain poorly understood. Here, we identify CD133 (Prominin-1), selectively expressed in basal-like triple-negative breast cancer (BL-TNBC) cells, acts as a key organizer of EV production and cargo composition. CD133 localizes to plasma membrane protrusions and lipid rafts, where it maintains membrane architecture, promotes EV release and directs selective cargo loading, including the pro-angiogenic factor CD105. Functionally, CD133

Indexed as

AC133 AntigenExtracellular VesiclesNeovascularization, PathologicTriple Negative Breast NeoplasmsAnimalsCell Line, TumorEndoglinFemaleHumansMiceAC133 AntigenEndoglinPROM1 protein, humanangiogenesisbreast cancerCD105 (endoglin)CD133 (Prominin‐1)extracellular vesicles

Identifiers

PMID42209429
PMCPMC13239947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.