Evidence map›Paper›PMID 42209417›Full record

ArticleSurgical infections2026

Outcomes and Predictors of Fungal Necrotizing Soft Tissue Infections.

Courtney Collins, Bradley Butsch, Mohammed Choudhary, Clark Ingram, Shachi Srivatsa, Pat Quinn, Nate Mowery, Anahita Jalilvand, Jonathan Wisler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Courtney CollinsDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Bradley ButschDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Mohammed ChoudharyDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Clark IngramDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Shachi SrivatsaDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Pat QuinnDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Nate MoweryDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Anahita JalilvandDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.
Jonathan WislerDepartment of Surgery, Division of Trauma, Critical Care, and Burn Surgery, Center for Translational Research in ACS, Critical Care, and Trauma (CTRACT), The Ohio State University, Columbus, Ohio, USA.

Funding

Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
Analyzing the long-term effects of DNA methylation meditated immunosuppression following sepsisR35GM150968 · NIGMS · OHIO STATE UNIVERSITY · PI Jon R Wisler · 2023 to 2026
$1.6M
The impact of obesity on neutrophil swarming in septic surgical patientsK08GM157658 · NIGMS · OHIO STATE UNIVERSITY · PI Anahita Jalilvand · 2024 to 2026
$572k
NIAID NIH HHS T32 AI106704NIGMS NIH HHS K08 GM157658NIGMS NIH HHS L30 GM155912NIGMS NIH HHS R35 GM150968
6 · The paper itself

Abstract

introductionFungal necrotizing soft tissue infections (NSTIs) are often diagnosed late due to the low likelihood, resulting in poor patient outcomes. Traditionally NSTI are treated with emergent surgical debridement followed by serial interventions. Adjunctive antibiotics are aimed at common bacterial infections along with toxin reduction; however, fungal treatment is often delayed. This study aimed to identify predictors, treatment patterns, and outcomes in fungal NSTIs.

methodsA retrospective review of patients with NSTIs (n = 634) from a single tertiary academic center was conducted from 2011 to 2023, with patients stratified by fungal presence in wound cultures. Primary outcomes were mortality along with the number of serial debridement. Secondary outcomes were length of stay, intensive care requirements, acute kidney injury, and 30-days readmission. Logistic regression was utilized to identify predictors of fungal infection.

resultsOf 634 patients, 110 (17.4%) had fungal-positive wound cultures, with

conclusionFungal NSTIs are associated with worse patient outcomes. Early empirical antifungal therapy may be considered in high-risk patients, particularly those with diabetes, as part of comprehensive NSTI management.

Indexed as

MycosesSoft Tissue InfectionsAgedDebridementFemaleHumansLength of StayMaleMiddle AgedNecrosisRetrospective StudiesRisk FactorsTreatment Outcomecritical carefungal infectionNSTIpredictorssurgical outcomes

Identifiers

PMID42209417
PMCPMC13355413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.