Observational studyBMJ paediatrics open2026
Breast milk-associated physiological hypercalcaemia: an observational study of clinical, biochemical and radiological outcomes.
Observational study in BMJ paediatrics open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
introductionAsymptomatic physiological hypercalcaemia in exclusively breastfed infants is recognised but has not been systematically characterised when breastfeeding is continued.
objectiveTo evaluate the clinical, biochemical and radiological outcomes of breast milk-associated physiological hypercalcaemia.
methodsA multi-centre retrospective study over 5 years included infants with hypercalcaemia (serum corrected calcium (cCa) ≥2.8 mmol/L) who were exclusively breastfed and had no other identifiable causes of hypercalcaemia. Clinical, biochemical and radiological data were analysed.
resultsTwenty-five infants (15 males, 10 females) were studied. The mean peak cCa was 3.08 mmol/L (SD 0.17; normal 2.2-2.8 mmol/L). All infants were asymptomatic and continued exclusive breastfeeding without interventions such as intravenous fluids, diuretics or bisphosphonates. Mean serum parathyroid hormone (PTH) was suppressed at 1.04 pmol/L (SD 0.9; reference 2.0-9.4 pmol/L). Renal ultrasound examinations performed in all infants showed no nephrocalcinosis. Hypercalcaemia resolved spontaneously over a median of 64 (range, 9-329) days, and the median duration of exclusive breastfeeding was 150 (range, 8-540) days.
conclusionBreast milk-associated physiological hypercalcaemia is a benign, PTH-independent condition without clinical symptoms or nephrocalcinosis. Infants can safely continue exclusive breastfeeding, preserving its well-established benefits, without switching to low calcium formulas. Further research is needed to elucidate the underlying mechanisms.
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