Evidence map›Paper›PMID 42209119›Full record

SynthesisJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Utility of Preclinical Dosimetry for First-in-Human Studies with PET Drugs Labeled with Common Radionuclides: A Systematic Review of Radiation Dose Estimates.

Hayoung Koo, Donika Plyku, Libero Marzella

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hayoung KooDivision of Imaging and Radiation Medicine, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Donika PlykuDivision of Imaging and Radiation Medicine, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland donika.plyku@fda.hhs.gov.
Libero MarzellaDivision of Imaging and Radiation Medicine, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

First-in-human studies of radiopharmaceuticals include an estimation of human radiation doses often extrapolated from preclinical biodistribution data. We reviewed radiation dose estimates derived from preclinical and clinical studies to determine the utility of preclinical dosimetry studies for estimating the human radiation dose of PET radiopharmaceuticals.

Indexed as

Positron-Emission TomographyRadiation DosageRadioisotopesRadiometryRadiopharmaceuticalsAnimalsDrug Evaluation, PreclinicalHumansIsotope LabelingTissue DistributionRadioisotopesRadiopharmaceuticalsdosimetryeffective dosePETpreclinicalradiopharmaceuticals

Identifiers

PMID42209119
PMCPMC13321985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.