Evidence map›Paper›PMID 42209028›Full record

ArticleBMJ case reports2026

Plasma metagenomic cfDNA sequencing identifies pathogens in culture-negative sepsis following urinary pouch rupture.

Katharina Hoeter, Linda Marriott, Elmo W I Neuberger, Urantschimeg Dagwadordsch, Radhe Shantha Kumar, Perikles Simon, Marc Bodenstein, Maïwenn Kersaudy-Kerhoas

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In one paragraph

Article in BMJ case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharina HoeterDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University Mainz Department of Anesthesiology, Mainz, Rheinland-Pfalz, Germany katharina.hoeter@unimedizin-mainz.de m.kersaudy-kerhoas@hw.ac.uk.ORCID http://orcid.org/0000-0003-4392-9672
Linda MarriottSchool of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland, UK.
Elmo W I NeubergerDepartment of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg University Mainz, Mainz, RP, Germany.
Urantschimeg DagwadordschInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, RP, Germany.
Radhe Shantha KumarUniversity of Cambridge, Cambridge, England, UK.
Perikles SimonDepartment of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg University Mainz, Mainz, RP, Germany.
Marc BodensteinDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University Mainz Department of Anesthesiology, Mainz, Rheinland-Pfalz, Germany.
Maïwenn Kersaudy-KerhoasSchool of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland, UK katharina.hoeter@unimedizin-mainz.de m.kersaudy-kerhoas@hw.ac.uk.ORCID http://orcid.org/0000-0002-8185-8230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A patient with a complex urological history presented with abdominal pain and respiratory distress after catheter dysfunction. She underwent emergency surgery for a ruptured urinary pouch. Sepsis was later diagnosed based on clinical deterioration, including tachycardia, fever, an elevated respiratory rate and raised inflammatory markers, but blood cultures remained negative. A metagenomic microbial cell-free DNA (cfDNA) assay (iSEP-SEQ), performed early from plasma as part of a research protocol, identified

Indexed as

Cell-Free Nucleic AcidsKlebsiella InfectionsPseudomonas InfectionsSepsisAnti-Bacterial AgentsFemaleHumansKlebsiellaMetagenomicsRupture, SpontaneousAnti-Bacterial AgentsCell-Free Nucleic AcidsBlood CultureHealthcare improvement and patient safetyHealth informaticsInfectious diseasesIntensive care

Identifiers

PMID42209028
PMCPMC13217375

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.