Evidence map›Paper›PMID 42208900›Full record

ArticleThe Journal of biological chemistry2026

Prenatal cannabinoid exposure alters excitation-inhibition balance through glutamate and GABA receptor-mediated signaling.

Priyanka D Pinky, Warren D Smith, Miles T Wiley, Jenna Bloemer, Vasiliki Syropoulou, Iva Durdanovic, Sharay E Setti, Jeremiah C Pfitzer, Savannah R Perman, Kawsar U Chowdhury and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Priyanka D PinkyDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Warren D SmithDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Miles T WileyDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Jenna BloemerDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA; Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Atlanta, Georgia, USA.
Vasiliki SyropoulouDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Iva DurdanovicDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA; Department of Electrical and Computer Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, Florida, USA.
Sharay E SettiDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Jeremiah C PfitzerDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Savannah R PermanDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Kawsar U ChowdhuryDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; School of Pharmacy, Keck Graduate Institute, The Claremont Colleges, Claremont, California, USA.
Kelli L McDonaldDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA.
Michael W GramlichCenter for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA; Physics Department, Auburn University, Auburn, Alabama, USA.
Subhrajit BhattacharyaSchool of Pharmacy, Keck Graduate Institute, The Claremont Colleges, Claremont, California, USA. Electronic address: Subhrajit_Bhattacharya@kgi.edu.
Vishnu SuppiramaniamDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA; Department of Molecular and Cellular Biology, College of Science and Mathematics, Kennesaw State University, Kennesaw, Georgia, USA. Electronic address: suppivd@auburn.edu.
Miranda N ReedDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA. Electronic address: reedmir@auburn.edu.

Funding

Elucidation of molecular mechanisms of prenatal cannabinoid exposure: Identification of targets and therapies.R01DA046723 · NIDA · KENNESAW STATE UNIVERSITY · PI REED, MIRANDA NICOLE, SUPPIRAMANIAM, VISHNU · 2020 to 2024
$1.6M
G-RISE at Auburn UniversityT32GM141739 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI CLAYTON, TAFFYE BENSON, RUSSELL, MELODY L · 2021 to 2024
$1.2M
NIDA NIH HHS R01 DA046723NIGMS NIH HHS T32 GM141739
6 · The paper itself

Abstract

The growing perception that marijuana is safe during pregnancy has led to a marked increase in prenatal cannabis use, raising concerns about its long-term effects on brain development and cognition. This study investigated the consequences of prenatal delta-9-tetrahydrocannabinol (THC) exposure on hippocampal circuit function, synaptic plasticity, and memory in adolescent offspring using a rodent model. We found that prenatal THC exposure resulted in persistent deficits in hippocampal-dependent memory and significant disruptions in synaptic plasticity, including impaired long-term potentiation and increased long-term depression. Electrophysiological analyses revealed reduced AMPAR-mediated synaptic transmission and a shift toward increased inhibitory signaling, suggesting an excitation/inhibition (E/I) imbalance in the hippocampus. These functional changes were accompanied by selective downregulation of postsynaptic glutamatergic proteins (GluA1, GluN2A, GluN2B, and PSD95), while presynaptic glutamate markers remained unchanged. Notably, immunohistochemical and anatomical analyses demonstrated region-specific reorganization of inhibitory networks, including altered distribution and colocalization of cannabinoid 1 receptor (CB

Indexed as

CannabinoidsDronabinolGlutamic AcidPrenatal Exposure Delayed EffectsReceptors, GABASignal TransductionAnimalsFemaleHippocampusMaleNeuronal PlasticityPregnancyRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Synaptic TransmissionCannabinoidsDronabinolGlutamic AcidReceptor, Cannabinoid, CB1Receptors, GABAadolescencebehaviorcannabinoidcannabisdevelopmentalglutamatemarijuanamemoryprenatalsynaptic plasticity

Identifiers

PMID42208900
PMCPMC13315650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.