Evidence map›Paper›PMID 42208545›Full record

ArticleCell reports. Medicine2026

Druggable β-catenin palmitoyl-switch coordinates immune evasion via immunogenic ferroptosis resistance and PD-L1-mediated immunosuppression.

Qiang Zhang, Yue Kong, Yinglin Long, Xue Li, Liang Wang, Zhanhao Luo, Xiaoya Yang, Yanchun Xie, Quanwei Yu, Jing Yu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Qiang ZhangZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China; Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China. Electronic address: zhangq539@mail.sysu.edu.cn.
Yue KongDepartment of Dermatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, China.
Yinglin LongDepartment of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Xue LiZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China.
Liang WangZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China.
Zhanhao LuoGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Xiaoya YangGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Yanchun XieGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Quanwei YuHeilongjiang Institute for Drug Control, Harbin 150088, China.
Jing YuDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China.
Dayi LiangDepartment of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.
Wenhao YuanZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China.
Xiaomin ChengZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China.
Yaqi SuZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China.
Kaisa CuiWuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, China.
Guobao TianZhongshan School of Medicine, Sun Yat-sen University Shenzhen Campus, Shenzhen, Guangdong 518107, China. Electronic address: tiangb@mail.sysu.edu.cn.
Zhen HeDepartment of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510655, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China. Electronic address: hezh5@mail.sysu.edu.cn.
Ping LanDepartment of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China; State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510655, China. Electronic address: lanping@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune evasion remains a major challenge in colorectal cancer (CRC) treatment. Here, we identify that druggable β-catenin palmitoylation at cysteine 466 (C466) by ZDHHC5 acts as a competitive switch, displacing S-nitrosylation and coordinating an immunosuppressive program. The palmitoylated state stabilizes the β-catenin/TCF4 complex, which simultaneously upregulates SLC7A11 to suppress immunogenic ferroptosis, critical for CD8

Indexed as

B7-H1 Antigenbeta CateninColorectal NeoplasmsFerroptosisImmune ToleranceTumor EscapeAcyltransferasesAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansImmunosuppression TherapyLipoylationMiceMice, Inbred C57BLAcyltransferasesB7-H1 Antigenbeta CateninCD274 protein, humancolorectal cancerimmunogenic ferroptosisimmunosuppressioninhibitorpalmitoylationPD-L1SLC7A11S-nitrosylationZDHHC5β-catenin

Identifiers

PMID42208545
PMCPMC13294000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.