Evidence map›Paper›PMID 42207871›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells.

Yosuke Nagahata, Yuji Nishimura, Ryota Kaitani, Jason Cheok Kuan Leong, Izumi Oda-Ishii, Hisanori Kohtsuka, Shinya Abe, Tasuku Ishida, Marina Carmona-Rivas, Sebastián R Najle and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yosuke NagahataLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0002-3157-4168
Yuji NishimuraLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Ryota KaitaniLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Jason Cheok Kuan LeongResearch Center for Integrative Evolutionary Science, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan.
Izumi Oda-IshiiDepartment of Zoology, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0001-5607-9588
Hisanori KohtsukaMisaki Marine Biological Station, School of Science, The University of Tokyo, Miura, Kanagawa 238-0225, Japan.
Shinya AbeLaboratory of Immune Regulation, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Tasuku IshidaDepartment of Zoology, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.ORCID 0009-0002-3698-2301
Marina Carmona-RivasDepartment of Complexity of Life, Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona 08003, Spain.
Sebastián R NajleDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona 08195, Spain.ORCID 0000-0002-0654-9147
Elena CasacubertaDepartment of Complexity of Life, Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona 08003, Spain.ORCID 0000-0002-8203-8357
Koichi IkutaLaboratory of Immune Regulation, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Toru MiuraMisaki Marine Biological Station, School of Science, The University of Tokyo, Miura, Kanagawa 238-0225, Japan.ORCID 0000-0002-7456-4402
Michio OgasawaraDepartment of Biology, Graduate School of Science, Chiba University, Chiba 263-8522, Japan.
Naoki IrieResearch Center for Integrative Evolutionary Science, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan.
Yutaka SatouDepartment of Zoology, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0001-5193-0708
Iñaki Ruiz-TrilloDepartment of Complexity of Life, Institut de Biologia Evolutiva (Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra), Barcelona 08003, Spain.ORCID 0000-0001-6547-5304
Hiroshi KawamotoLaboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Funding

Consejo Superior de Investigaciones Científicas (CSIC) PIE-202120E047- Conexiones-LifeGeneralitat de Catalunya (Government of Catalonia) exp. 2021 SGR 00751Kyoto University LiMe Office of Director's Research Grants 2022 (No. 6)Kyoto University LiMe Office of Director's Research Grants 2023 (No. 7)Kyoto University The Cooperative Research Program 2022MEXT | Japan Society for the Promotion of Science (JSPS) JP 19H05747MEXT | Japan Society for the Promotion of Science (JSPS) JP 202460347MEXT | Japan Society for the Promotion of Science (JSPS) JP 23K15324MICIU/AEI/10.13039/501100011033 and FSE+ (Spain) RYC2023-0 45787-IMinisterio de Ciencia, Innovación y Universidades (MCIU) PID2023-153273NB-I00
6 · The paper itself

Abstract

Blood cells are common and unique to animals, enabling them to address critical challenges of defense and transport. Thus, their evolution represents a defining innovation in metazoan multicellular life. However, their evolutionary trajectory about how blood cells emerged and diversified throughout animal history remains unclear. Here, we present a combination of bioinformatics and functional data that demonstrate that the metazoan blood cell program most likely originated through the repurposing of an ancestral premetazoan toolkit governed by

Indexed as

Biological EvolutionBlood CellsAnimalsCell DifferentiationCell LineageMacrophagesMast CellsPhylogenyblood cellevolutionmast cellthymusunicellular organism

Identifiers

PMID42207871
PMCPMC13250551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.