ArticlePloS one2026
Lung ultrasonography to assess efficacy of intranasal and parenteral vaccinations for bovine respiratory disease (BRD) in dairy calves.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Vaccination is used to control bovine respiratory disease (BRD). The aim of this study was to evaluate BRD vaccine efficacy through the lung lesions area in dairy calves, also discriminating the lung health status at vaccine administration. One hundred forty-nine dairy calves were enrolled and divided according to vaccine protocol and initial lung condition: healthy (H-CTR; n = 17) and diseased (D-CTR; n = 24) control group; healthy (H-INT; n = 28) and diseased (D-INT; n = 18) intranasal group, healthy (H-VAC; n = 31) and diseased (D-VAC; n = 31) intranasal and parenteral group. Intranasal vaccination was against bovine parainfluenza-3 and respiratory syncytial viruses, while parenteral vaccination was also against Mannheimia haemolytica. Animals were assessed by clinical and ultrasonographical examinations at 10, 17, 38, 52 days; ultrasonography and lung lesion scores (US and LLS), and total consolidation area (TC_A) were greater in CTR with increasing levels over time in both H-CTR (US: 1.45 at 10d vs. 3.8-4.4 thereafter; LLS: 3.5 at 10d vs. 12.4-13.3 thereafter; TC_A: 3.9 cm2 at 10d vs. 9.8-15.4 cm2 thereafter) and D-CTR groups (LLS: 12.1 at 10d vs. 13.0-15.7 thereafter; TC_A: 23.4 cm2 at 10d vs. 34.9-49.4 cm2 thereafter). However, TC_A was maintained in H-INT and reduced in D-INT (22.3 cm2 at 10d vs. 14.3 cm2at 52d). The VAC had the lowest values in US, LLS and TC_A. The H-VAC preserved the initial condition for these parameters, while D-VAC showed a reduction in US (3.8 at 10d vs. 3.0 at 52d) and TC_A (18.4 cm2 at 10d vs. 10.9 cm2 at 52d). In conclusion, the combination of intranasal and parenteral vaccination reduced the progression of lung TC_A severity in both initially healthy and diseased female dairy calves.
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