Evidence map›Paper›PMID 42207691›Full record

ArticleJournal of bacteriology2026

The versatility of the CHASE domain in one-component systems of c-di-GMP signal transduction from

Simone Angeli, Chiara Scribani-Rossi, Giulio Colasanto, Sharon Spizzichino, Serena Rosignoli, Alessandra Giorgi, Francesca Cutruzzolà, Alessio Paone, Angela Tramonti, Roberto Contestabile and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simone Angeli *Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Chiara Scribani-Rossi *Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Giulio ColasantoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Sharon SpizzichinoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Serena RosignoliCentre for Regenerative Medicine "Stefano Ferrari", Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Alessandra GiorgiDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Francesca CutruzzolàDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Alessio PaoneDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Angela TramontiIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.ORCID 0000-0002-5625-1170
Roberto ContestabileDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-5235-9993
Robert MontoyaGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
George A O'TooleGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-2861-4392
Alessandro PaiardiniDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Serena RinaldoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-0682-023X

Funding

Project ECS 0000024 Rome Technopole, - CUP B83C22002820006, NRP Mission 4. Component 2 Investment 1.5, Funded by the European Union - NextGenerationEU CUP B83C22002820006Sapienza Università di Roma (Sapienza) AR223188B4A2457ESapienza Università di Roma (Sapienza) RM123188F4549144
6 · The paper itself

Abstract

Cyclic di-GMP (c-di-GMP) is a key bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation and virulence. Multi-domain one-component systems regulate c-di-GMP synthesis and turnover in response to external signals. Periplasmic sensing of environmental cues is performed by versatile but conserved sensory domains, including members of the CHASE4 superfamily. Here, we explore the promiscuity of the CHASE4 domain in c-di-GMP signal transduction in

Indexed as

Bacterial ProteinsCyclic GMPPseudomonas aeruginosaSignal TransductionCopperEscherichia coli ProteinsHemePhosphorus-Oxygen LyasesProtein DomainsBacterial Proteinsbis(3',5')-cyclic diguanylic acidCopperCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsHemePhosphorus-Oxygen Lyasesbiofilmc-di-GMPcopperhemePseudomonas aeruginosa

Identifiers

PMID42207691
PMCPMC13277305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.