ReviewGut microbes2026
The impact of gut microbiota and metabolite-driven immune cell spatiotemporal dynamics on tumors.
Review in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
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Abstract
Cancer poses a significant threat to human health. The immune response plays a pivotal role in tumor cell elimination, with increasing attention given to the spatiotemporal dynamics of immune cells across temporal, spatial, and functional dimensions. The gut microbiota, which constitutes the majority of the human microbiome, contributes to tumor initiation and progression. The tumor microenvironment (TME) serves as the primary site for immune cell-mediated anti-tumor responses, with the gut microbiota and its metabolites driving immune cell activation and spatiotemporal remodeling. This review explores the mechanisms by which the gut microbiota and its metabolites influence anti-tumor immunity, alongside the impact of immune cell dynamics on tumors. Furthermore, it proposes novel research strategies, including the "gut microbiota-immune cell dynamic monitoring model" and the "organoid-microbe co-culture platform." This work lays a theoretical foundation for advancing our understanding of the underlying mechanisms and developing innovative therapeutic approaches.
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