ArticleInfection2026
vanA-consistent phenotype vancomycin-resistant enterococcal colonization is associated with inferior overall survival in acute myeloid leukemia patients undergoing intensive chemotherapy: a single-center retrospective study.
Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVancomycin-resistant enterococci (VRE) colonization is common among patients with acute myeloid leukemia (AML) undergoing intensive chemotherapy. Whether the teicoplanin-defined VRE phenotype, specifically vanA-consistent (teicoplanin-resistant) versus vanB-consistent (teicoplanin-susceptible), is associated with adverse outcomes is unknown.
methodsWe conducted a retrospective single-center cohort study of 192 VRE-colonized AML patients who received intensive induction chemotherapy between 2015 and 2024. vanA-consistent phenotype (n = 35, 18.2%) was defined as VRE isolates demonstrating vancomycin (MIC > 4 mg/l) and teicoplanin resistance (MIC > 2 mg/L). vanB-consistent phenotype (n = 157, 81.8%) was defined as VRE isolates susceptible to teicoplanin. The primary endpoint was overall survival (OS). Cox proportional hazards regression estimated the association between VRE phenotype and OS with adjustment for ELN 2022 genetic risk, sex, ECOG performance status, and allogeneic stem cell transplantation. Healthcare-exposure variables were compared between phenotypes, and the interaction between vanA-consistent phenotype and cumulative inpatient days before VRE detection was evaluated.
resultsvanA-consistent phenotype patients had significantly inferior OS compared with vanB-consistent phenotype patients (3-year OS 46.1% vs. 73.2%; log-rank p = 0.004). vanA-consistent phenotype was strongly associated with adverse-risk ELN 2022 genetics (54% vs. 24%; OR 3.69, p < 0.001). Despite this association, vanA-consistent phenotype remained associated with OS after adjustment for ELN 2022 risk, sex, ECOG, and allo-SCT (HR 1.85, 95% CI 1.03-3.34, p = 0.041). The vanA-associated hazard increased with longer cumulative inpatient exposure before VRE detection. No significant differences were observed for infection-related complications between vanA- and vanB-consistent phenotypes.
conclusionsvanA-consistent phenotype VRE colonization is an adverse prognostic factor in VRE-colonized AML patients, providing prognostic information beyond ELN 2022 genetic risk classification. To our knowledge, this is the first study to demonstrate differential outcomes by teicoplanin-defined VRE phenotype. Despite enrichment for adverse-risk genetics in vanA-consistent phenotype patients, this did not fully account for the survival disadvantage. Prospective multicenter validation is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.