ArticleCardiovascular drugs and therapy2026
Citrated Kaolin Reaction Time on Thromboelastography 6s Identifies Bleeding-Prone Phenotypes in Older Adults with Atrial Fibrillation Receiving Direct Oral Anticoagulant Therapy.
Article in Cardiovascular drugs and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeOlder adults with atrial fibrillation (AF) receiving direct oral anticoagulants (DOACs) remain at increased bleeding risk, and conventional clinical scores offer limited predictive value. Thromboelastography (TEG6s) provides point-of-care assessment of global hemostasis; however, its clinical utility remains unclear. This study investigated the association between TEG6s parameters and bleeding events in older adults with AF receiving DOAC therapy.
methodsWe prospectively enrolled 100 patients aged ≥ 75 years with non-valvular AF receiving DOAC therapy. Baseline TEG6s parameters, including citrated kaolin reaction time (CKR), were obtained. Bleeding events were classified per International Society on Thrombosis and Haemostasis criteria. Logistic regression and receiver operating characteristic (ROC) analyses identified predictors of clinically relevant bleeding, defined as major and clinically relevant non-major bleeding.
resultsClinically relevant bleeding occurred in 33 patients during a 1-year follow-up. Prolonged CKR was independently associated with increased bleeding risk in multivariate analysis (hazard ratio 1.36; 95% confidence interval: 1.10-1.70; p = 0.005). ROC analysis demonstrated fair discriminative performance for CKR (area under the curve = 0.712), suggesting a potential role as a biomarker for bleeding risk stratification. Other TEG parameters and conventional clinical risk scores were not significant predictors.
conclusionProlonged CKR was significantly associated with clinically relevant bleeding events in older adults with AF receiving DOAC therapy. CKR may reflect an underlying bleeding tendency and could serve as an investigational biomarker for bleeding risk stratification. However, its clinical utility requires confirmation in larger, multicenter studies.
Indexed as
Identifiers
42207444What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.