Trial reportJournal of neuro-oncology2026
Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients - results of a prospective phase II trial (INTRAMET).
Trial report in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBrain metastases occur in approximately 20% of cancer patients. Surgical resection followed by radiotherapy is a standard approach for symptomatic lesions. Intraoperative radiotherapy (IORT) enables immediate irradiation of the resection cavity and may facilitate treatment integration. We conducted a prospective phase-II-trial to evaluate the efficacy and safety of low-energy X-ray IORT following resection of brain metastases.
methodsINTRAMET was an open-label, single-arm study enrolling patients with suspected brain metastases between 2017 and 2022. Following resection and frozen-section confirmation of metastatic disease, IORT was delivered to the resection cavity using a mobile low-energy X-ray device. A dose of 30 Gy was prescribed to the applicator surface. Primary endpoint was local control. Secondary endpoints included distant brain control, overall survival, time to initiation of subsequent systemic therapy, and treatment-related adverse events.
resultsThirty-five patients were included. Median follow-up was 25.7 months. Median patient age was 64 years, and 68.6% of metastases originated from lung cancer. Local control was 94.3% (95% CI, 82.9-98.8%), while distant brain control was 57.1% (95% CI, 40.7-72.4%). Median overall survival was 43.6 months. Radionecrosis occurred in 20% of patients, predominantly low grade; no grade 4 or 5 IORT-related toxicities were observed. Leptomeningeal dissemination outside the irradiated field occurred in 8.6% of patients. Median time to initiation of subsequent systemic therapy was 45 days.
conclusionIORT to the resection cavity was associated with favorable local control and an acceptable safety profile. It may represent a feasible alternative to postoperative stereotactic radiosurgery in selected patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.