Evidence map›Paper›PMID 42207332›Full record

ArticleExperimental brain research2026

Vitamin C mitigates early auditory cortical hyperexcitability and antioxidant imbalance induced by acute intermittent hypoxia.

Yue Wu, Tao Li, Wanxin Cao, Rui Fan, Hailing Jiang, Jiachen Han, Furong Ma, Yan Yan

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yue Wu *Department of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China.
Tao Li *Department of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China.
Wanxin CaoDepartment of Otolaryngology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Rui FanDepartment of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China.
Hailing JiangDepartment of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China.
Jiachen HanDepartment of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China.
Furong MaDepartment of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China. furongma@126.com.
Yan YanDepartment of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing, 100191, China. yanyan_ent@bjmu.edu.cn.

Funding

Clinical Cohort Construction Project of Peking University Third Hospital BYSYDL2025039
6 · The paper itself

Abstract

To test whether brief intermittent hypoxia (IH) induces early hyperexcitability and antioxidant imbalance in the primary auditory cortex (Au1) of rats, and whether high-dose vitamin C (VC) pretreatment mitigates these effects. Adult male Sprague-Dawley rats were assigned to four groups (n = 6/group): control, IH, IH plus intraperitoneal normal saline (IH+IPNS), and IH plus intraperitoneal VC (IH+IPVC). Rats underwent a single 3 h IH protocol; VC (500 mg/kg, intraperitoneal injection) or saline was administered 30 min before IH. Three hours after IH, in vivo Au1 multiunit recordings quantified spontaneous firing rate (SFR). We quantified catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and assessed apoptosis using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Acute IH increased Au1 SFR versus control, and saline did not alter this response; VC pretreatment reduced SFR toward control levels. IH decreased CAT activity and increased SOD activity, with minimal change in GPx. VC increased CAT, SOD, and GPx activities relative to IH. No overt neuronal apoptosis was detected in Au1. Acute IH induces early Au1 dysfunction characterized by hyperexcitability and antioxidant imbalance. High-dose VC pretreatment attenuates hyperexcitability and enhances antioxidant enzyme activity, suggesting a potential protective role of antioxidant strategies in the central auditory system.

Indexed as

AntioxidantsAscorbic AcidAuditory CortexHypoxiaAction PotentialsAnimalsApoptosisCatalaseGlutathione PeroxidaseIn Situ Nick-End LabelingMaleNeuronsRatsRats, Sprague-DawleySuperoxide DismutaseAntioxidantsAscorbic AcidCatalaseGlutathione PeroxidaseSuperoxide DismutaseAntioxidant enzymesAuditory cortexIntermittent hypoxiaNeuronal excitabilityVitamin C

Identifiers

PMID42207332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.