Evidence map›Paper›PMID 42207205›Full record

ArticlePediatric surgery international2026

Bowel and bladder outcomes in patients with anorectal malformations and sacral agenesis: a retrospective cohort study.

J N Theeuwes, C M C de Beaufort, C J McDonald, D P Bakker, J van Schuppen, C F Kuijper, O E Arguedas Flores, J R de Jong, M E B Kremer, R R Gorter

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

J N TheeuwesDepartment of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. j.n.theeuwes@amsterdamumc.nl.
C M C de BeaufortDepartment of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
C J McDonaldDepartment of Pediatric Neurology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
D P BakkerDepartment of Pediatric Neurology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
J van SchuppenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
C F KuijperDepartment of Pediatric Urology, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
O E Arguedas FloresDepartment of Pediatric Urology, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
J R de JongDepartment of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
M E B KremerDepartment of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
R R GorterDepartment of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with anorectal malformation (ARM) and associated sacral agenesis (SA) are at increased risk of long-term bowel and bladder dysfunction, but outcome data to guide early counselling and follow-up remain limited. We aimed to evaluate bowel and bladder outcomes in patients with concurrent ARM and SA, with a focus on transanal irrigation (TAI) and clean intermittent catheterization (CIC) use.

methodsIn this retrospective single-center cohort study, all patients with ARM and SA born between January 2000 and January 2024 were included. SA was diagnosed radiologically and classified using Pang's classification. The primary outcome was TAI and/or CIC use. Secondary outcomes included fecal incontinence (≥ 4 years), urinary incontinence (≥ 5 years), and neurogenic bladder.

resultsIn total, 41 patients were included, with a median age at follow-up of 11.2 years. Of 33 patients ≥ 4 years, 22 (66.7%) used TAI during follow-up, primarily for fecal incontinence. Fecal incontinence was present in 26.3% of current TAI users versus 71.4% of non-users (p = .015). CIC was initiated in 18 of 41 patients (43.9%), mostly due to urodynamically confirmed neurogenic bladder. TAI and CIC use were associated with ARM complexity, but not with radiological SA severity.

conclusionPatients with concurrent ARM and SA represent a high-risk group for long-term bowel and bladder dysfunction, and many require structured bowel and/or bladder management. These findings support anticipatory counselling and multidisciplinary follow-up.

Indexed as

Abnormalities, MultipleAnorectal MalformationsFecal IncontinenceSacrococcygeal RegionSacrumUrinary Bladder, NeurogenicUrinary IncontinenceChildChild, PreschoolFemaleFollow-Up StudiesHumansIntermittent Urethral CatheterizationMaleMeningoceleRetrospective StudiesAnorectal malformationClean intermittent catheterizationFecal incontinenceNeurogenic bladderSacral agenesisTransanal irrigation

Identifiers

PMID42207205
PMCPMC13219063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.