ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Relationship between salivary inflammatory mediators and oral dryness during chemotherapy in patients with cancer: a cohort study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the association between salivary inflammatory mediators and oral dryness during oral mucositis development in patients with cancer undergoing chemotherapy.
methodsThis prospective cohort study (time-stratified sampling) enrolled adult patients undergoing chemotherapy or chemoradiotherapy at Niigata University Medical and Dental Hospital (November 2021-August 2023). Sample size was determined a priori from a pilot study. Oral mucosal status was graded using the World Health Organization oral toxicity scale, and oral moisture was measured (dryness < 28). Unstimulated whole saliva was analyzed for interleukins (IL)-1β, IL-6, IL-8, IL-10, IL-12p70, tumor necrosis factor (TNF), prostaglandin E2, and vascular endothelial growth factor via cytometric bead array and enzyme-linked immunosorbent assay. Clinical data included demographics, treatment, and days post-chemotherapy (0-7, 8-14, ≥ 15). TNF and IL-10 were independently associated with oral dryness; cutoffs were median levels in patients with grade 0 mucositis.
resultsAmong 162 patients, 56 (34.6%) had oral dryness. Dryness was associated with higher neutrophil counts (median: 3.23 vs. 3.00 × 10
conclusionsSalivary TNF and IL-10 levels and sampling timing after CT were associated with oral dryness, suggesting temporal changes in salivary inflammatory mediators.
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