ArticleBiomaterials science2026
Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions.
Haofu Huang, Jingya Qin, Sirui Shen, Jeongmin Hwang, Darrin J Pochan, Kristi L Kiick
Abstract read
In one paragraphArticle in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Haofu HuangDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA. pochan@udel.edu.
Jingya QinDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, USA. pochan@udel.edu.
Jeongmin HwangDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.
Funding
Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2MThis renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8MUnderstanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1MPilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2014 to 2018
$5.8MCOBRE on Membrane Protein Production and CharacterizationP30GM103519 · NIGMS · UNIVERSITY OF DELAWARE · PI LENHOFF, ABRAHAM M · 2012 to 2014
$3.3MCollagen-mediated approaches to improve the local delivery and hypothermic release of osteoarthritis therapeuticsR01AR080707 · NIAMS · UNIVERSITY OF DELAWARE · PI Christopher Price · 2023 to 2026
$2.4MAcquisition of a Zeiss LSM710 Confocal MicroscopeS10RR027273 · NCRR · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2010 to 2010
$494kZeiss LSM710 Inverted Confocal MicroscopeS10OD016361 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2015 to 2015
$444kCollagen-based targeting for improving delivery and efficacy of osteoarthritis drugsR21AR069778 · NIAMS · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L, PRICE, CHRISTOPHER · 2017 to 2018
$365kNCRR NIH HHS S10 RR027273NIAMS NIH HHS R01 AR080707NIAMS NIH HHS R21 AR069778NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P20 GM139760NIGMS NIH HHS P30 GM103519NIGMS NIH HHS P30 GM110758NIH HHS S10 OD016361
6 · The paper itselfAbstract
Elastin-collagen nanoparticles (ECnPs) have been shown in our previous studies to self-assemble into different morphologies, including nanoplates and nanovesicles, by manipulating the sequence length of the elastin-like peptide (ELPs) and collagen-like peptide (CLPs) of a given conjugate. In this work, we demonstrate that the morphologies of ECnPs can also be modulated, for a given ECnP sequence, with variations in solution pH and/or the amount of encapsulated drug. Specifically, the peptide (VPGYG)
Indexed as
CollagenDexamethasoneDrug CarriersElastinNanoparticlesPeptidesAmino Acid SequenceFluoresceinsHydrogen-Ion Concentration6-carboxyfluoresceinCollagenDexamethasoneDrug CarriersElastinFluoresceinsPeptides
Identifiers
PMID42206973
PMCPMC13218328
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