Evaluation of combination therapy duration for endocarditis secondary to Enterobacterales.

Sunish Shah, Jake Smith, Brandon J Smith, Ryan K Shields

Abstract readMulticenter Study

In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sunish ShahAntibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8873-1451

Jake SmithAntibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Brandon J SmithAntibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Ryan K ShieldsAntibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9794-5665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combination antimicrobial treatment for endocarditis secondary to Enterobacterales may be associated with clinical benefits, but this benefit comes with an increased risk of adverse drug reactions (ADRs). We hypothesized that short-course combination therapy would optimize clinical benefits while minimizing ADRs. This was a retrospective, multicenter study of adult patients with definitive endocarditis secondary to Enterobacterales. Short-course combination treatment was defined as receipt of combination therapy for ≤14 days. Seventy-three patients met the inclusion criteria.

Indexed as

Anti-Bacterial AgentsEndocarditis, BacterialEnterobacteriaceae InfectionsSerratia InfectionsAgedAminoglycosidesDrug Therapy, CombinationEnterobacteriaceaeFemaleHumansMaleMiddle AgedRetrospective StudiesSerratia marcescensAminoglycosidesAnti-Bacterial Agentscombinationdurationendocarditisenterobacterales

Identifiers

PMID42206916

DOI10.1128/aac.00357-26

PMCPMC13321831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.