ArticleJournal of the American Chemical Society2026
Deprotonative Single-Electron Oxidation as a General and Controllably Selective Platform for Benzylic C-H Functionalization.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Deprotonative Single-Electron Oxidation as a General and Controllably Selective Platform for Benzylic C-H Functionalization.Journal of the American Chemical Society · 2026Article
- Harnessing redox properties of organic persistent radicals in SET-induced transformations.Beilstein journal of organic chemistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a new strategy for benzyl radical generation through a consecutive deprotonation and single-electron oxidation mechanism. The use of an HMDS base generates a low concentration of a benzyl carbanionic intermediate that is oxidized and subsequently captured using two equivalents of the persistent aminoxyl radical reagent TEMPO. Compared to oxidation reactions of stoichiometrically prepared carbanionic species, endergonic deprotonation ensures selective radical coupling over dimerization and enables a major improvement in functional group tolerance and site-selectivity control. This approach is guided by C-H acidity and carbanion oxidation trends and therefore exhibits distinct scope and selectivity over hydrogen atom abstraction and direct single-electron oxidation-based methods that are instead guided by alkylarene C-H bond strengths or oxidation potentials, respectively. As such, this protocol is applicable to alkylarenes with high oxidation potentials and tolerates the presence of weak C-H bonds and oxidatively sensitive functional groups. These features enable TEMPO installation on densely functionalized compounds, including pharmaceutical and
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.