ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2026
Quality of life, stigma, and mental health, in individuals affected by leprosy: a cross-sectional study.
Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLeprosy rarely causes death but leads to disfigurement, stigma, and disability, resulting in socioeconomic consequences. Understanding these inter-related factors is essential for developing effective interventions. This study aimed to assess QoL and mental health among individuals affected by leprosy and to examine identify QoL predictors.
methodsA cross-sectional study was conducted in urban leprosy rehabilitation centres in Ethiopia. A total of 370 individuals were enrolled. Correlation and multivariable regression analyses were used to examine associations and identify predictors of QoL.
resultsParticipants were predominantly male (54.1%) and aged ≥61 years (42.8%). Most had no education (57.3%), while only 4.3% had secondary education or above; one-half were married. Poor living conditions were reported in 84.05% of participants, while delayed diagnosis (≥2 years after symptom onset) was observed in 53% of cases. The median social relationship QoL score was 7 (IQR 5-9), while that for overall QoL was 61 (IQR 56-68). Median sleep score was 8 (IQR 6-11). Stigma correlated positively with anxiety (r = 0.206) and depression (r = 0.269) and negatively with QoL (r = -0.251). Anxiety and depression were strongly correlated (r = 0.794, P < .001).
conclusionsStigma, psychological distress and poor sleep impair QoL among people affected by leprosy, highlighting the need for multidisciplinary interventions.
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