Evidence map›Paper›PMID 42206661›Full record

ArticlePsychological medicine2026

Integrative multi-omics identifies

Chengsong Yuan, Bo Zhang, Yuanyuan Liang, Junze Ran, Shiyi Hu, Andi Liu, Yuran Liu, Fengqin Qin, Lingqi Jian, Yongji He and 2 more

Abstract read
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chengsong YuanMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Bo ZhangMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Yuanyuan LiangDepartment of Nephrology, Sixth People's Hospital of Chengdu, China.
Junze RanMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Shiyi HuMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Andi LiuMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Yuran LiuMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Fengqin QinDepartment of Neurology, https://ror.org/01c4jmp52The 3rd Affiliated Hospital of Chengdu Medical College, China.
Lingqi JianMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.
Yongji HeClinical Trial Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital of Sichuan University, China.
Feng HanDepartment of Emergency Medicine, https://ror.org/030sr2v21Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, China.
Chengcheng ZhangMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, Sichuan University West China Hospital Mental Health Center, China.ORCID 0000-0002-2992-6291

Funding

China Postdoctoral Science Foundation 2020M673247
6 · The paper itself

Abstract

backgroundCurrent bipolar disorder (BD) therapies suffer from limited efficacy and adverse effects, necessitating mechanistically grounded targets.

methodsWe integrated BD genome-wide association study data (158,036 cases; 2,796,499 controls) with brain proteomics (ROSMAP and Banner dorsolateral prefrontal cortex,

resultsPWAS identified eight BD-associated genes (false discovery rate < 0.05), with

conclusionsOur convergent multi-omics framework highlights

Indexed as

Bipolar DisorderCalcium-Binding ProteinsNerve Tissue ProteinsGenome-Wide Association StudyHippocampusHumansMolecular Docking SimulationMultiomicsPrefrontal CortexProteomicsCalcium-Binding ProteinsNerve Tissue Proteinsbipolar disorderdifferential expression analysisDOC2Adrug targetMendelian randomizationPWAS

Identifiers

PMID42206661
PMCPMC13234528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.