ArticleJournal of applied clinical medical physics2026
Implementation and Dosimetric Evaluation of a Knowledge-Based IMRT Model for Left-Sided Breast Radiotherapy with DIBH.
Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to dosimetrically evaluate the plan quality of a knowledge-based planning (KBP) model developed from intensity-modulated radiation therapy (IMRT) plans for left-sided breast cancer treated with deep inspiration breath hold (DIBH), and to assess its clinical applicability. MATERIALS AND
methodsEighty patients previously treated with DIBH were included. A RapidPlan-based KBP model was developed using clinically approved plans (ClinP) within a Halcyon-equivalent workflow on the Ethos platform. Dosimetric performance of model-only plans (KBP) and plans refined with limited manual optimization (KBP+MP) was compared against ClinP for planning target volume (PTV) coverage and organ-at-risk (OAR) sparing.
resultsThe KBP model demonstrated satisfactory training performance, with acceptable coefficients of determination (R DISCUSSION: Our findings support the clinical applicability of KBP. While KBP effectively reduces high-dose regions, it may increase low-dose exposure particularly in distant OARs such as the contralateral lung and breast. The KBP+MP approach provided more balanced OAR sparing while simplifying the overall planning workflow compared with manual methods.
conclusionThe KBP model demonstrated clinical feasibility for left-sided breast IMRT under DIBH conditions. Model-generated plans achieved target coverage comparable to clinically approved plans while providing acceptable OAR sparing. Although KBP alone tended to increase low-dose exposure in contralateral structures, limited manual refinement improved overall dose balance. These findings support the integration of structured KBP workflows into standardized DIBH breast IMRT planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.