ArticleJournal of applied clinical medical physics2026
Characterization of dosimetric predictors for pulmonary perfusion changes before and after hypofractionated whole-breast radiotherapy in node-negative breast cancer patients: A prospective study.
Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBreast cancer is the most common malignancy in women, and adjuvant radiotherapy is an essential component of curative treatment. Despite advances in hypofractionated whole-breast irradiation (HF-WBI), incidental lung exposure remains unavoidable and predisposes to radiation-induced pulmonary injury, including radiation pneumonitis (RP). Traditional predictors such as mean lung dose (MLD) may inadequately capture the heterogeneous intrapulmonary dose distribution typical of breast radiotherapy. PURPOSE: The purpose of this study was to evaluate whether heterogeneity-sensitive dosimetric metrics and functional lung imaging better predict radiation-induced perfusion changes and RP in patients undergoing HF-WBI.
methodsIn this prospective study, 48 node-negative breast cancer patients treated with conformal HF-WBI were evaluated. Pulmonary perfusion scans (PPS) were acquired pre-RT and 6-9 months post-RT. Dose-volume histogram (DVH) parameters, including MLD, uniform effective dose (D
resultsPPS revealed modest but detectable post-RT perfusion declines, most pronounced in lung regions receiving higher doses. Three patients (6.3%) developed Grade 2 RP. D
conclusionsD
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