Evidence map›Paper›PMID 42206554›Full record

ArticleInsect molecular biology2026

Sex-biased DNA methylation in small hive beetles (Aethina tumida).

Qiang Huang, Ryszard Maleszka, Jay D Evans

Abstract read
In one paragraph

Article in Insect molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qiang HuangHoney Bee Research Institute, Jiangxi Agricultural University, Nanchang, China.ORCID https://orcid.org/0000-0001-5528-5099
Ryszard MaleszkaResearch School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID https://orcid.org/0000-0003-1855-555X
Jay D EvansUSDA, Agricultural Research Service, Beltsville Agricultural Research Center, Bee Research Laboratory, Beltsville, Maryland, USA.

Funding

initiation package of Jiangxi Agricultural University 050014/923230722.
6 · The paper itself

Abstract

DNA methylation is an important epigenomic modification that significantly influences various cellular and organismal functions. In this study, we investigate the methylome of the small hive beetle, Aethina tumida. Our analysis reveals an average of 58,306 CpG methylation marks per beetle, representing approximately 0.99% of the genome's total CpGs. Notably, 85.4% of these methylation marks are located within genic regions on autosomes, with similar rates observed in both male and female beetles. However, male beetles exhibit a lower number of methylation marks and upregulated genes on Chromosome X when compared to female beetles. To evaluate the impact of epialleles on methylation, we identified 5828 associations between SNPs and methylation, with genotypes accounting for 39.2% of the variation observed at highly methylated sites. Interestingly, unfertilised eggs display slightly higher levels of DNA methylation compared to adult beetles, whereas embryos show methylation levels that are only about half of those in adults. This suggests that DNA methylation is dynamic during early development.

Indexed as

ColeopteraDNA MethylationAnimalsCpG IslandsEpigenesis, GeneticFemaleMalePolymorphism, Single NucleotidebeetleDNA methylationDNMTepigeneticsgene expressionsexSNP

Identifiers

PMID42206554
PMCPMC13551503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.