Spotlight on the Nucleotide: Solid-State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC.

Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nina WehrInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.

Laure DecampsMax Planck Institute For Chemical Energy Conversion, Mülheim an der Ruhr, Germany.ORCID https://orcid.org/0000-0002-4572-7479

Julius SchlüterInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0006-1202-8731

Koen LinssenInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0008-6970-8302

Georg KünzeInstitute for Drug Discovery, Leipzig University, Leipzig, Germany.ORCID https://orcid.org/0000-0003-1799-346X

Kushal SenguptaMax Planck Institute For Chemical Energy Conversion, Mülheim an der Ruhr, Germany.ORCID https://orcid.org/0000-0002-5941-406X

Serena DeBeerMax Planck Institute For Chemical Energy Conversion, Mülheim an der Ruhr, Germany.ORCID https://orcid.org/0000-0002-5196-3400

Thomas WiegandInstitute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0003-3655-6150

Funding

Deutsche ForschungsgemeinschaftMax-Planck-Gesellschaft

6 · The paper itself

Abstract

Solid-state nuclear magnetic resonance (NMR) spectroscopy is an ideal tool to study ATP hydrolysis in ATP-driven processes at atomic resolution. In this study, we present a nucleotide-detected solid-state NMR approach to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P-loop ATPase SmsC as a model protein.

Indexed as

Adenosine TriphosphatasesAdenosine TriphosphateNucleotidesHydrogen BondingHydrolysisMagnetic Resonance SpectroscopyModels, MolecularNuclear Magnetic Resonance, BiomolecularAdenosine TriphosphatasesAdenosine TriphosphateNucleotidesATP analoguesATP hydrolysisphosphorus‐31real‐time NMRsolid‐state NMR

Identifiers

PMID42206515

DOI10.1002/chem.71171

PMCPMC13569932

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.