Evidence map›Paper›PMID 42206408›Full record

ArticleAdvanced healthcare materials2026

Long-Term Hydrophilic, Anti-Clotting, and Anti-Fibrotic Dynamic Covalent Silicone-Based Biomaterials.

Norma A Garza Flores, Eva Mueller, Robert Bui, James C Fredenburgh, Ruiqi Yin, Rawaa Hussain, Rida A Malik, Thomas Kalab, Dabeer Abdul-Azeez, Fei Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Norma A Garza FloresDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Eva MuellerDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Robert BuiDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
James C FredenburghDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Ruiqi YinDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0001-6890-9964
Rawaa HussainDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Rida A MalikDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0001-7118-8715
Thomas KalabDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Dabeer Abdul-AzeezDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Fei XuDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Michael BrookDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
Jeffrey I WeitzDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Todd HoareDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2017-06455NSERC CREATE Training Program for Controlled Release Leaders
6 · The paper itself

Abstract

While polydimethylsiloxane (PDMS) has been widely applied in biomedical devices and implants, its interfacial hydrophobicity and poor blood compatibility limit its long-term effectiveness. Existing approaches to enhance the surface hydrophilicity and reduce the interfacial biological responses of PDMS implants often result in a gradual loss of hydrophilicity due to the chemical instability of the coating and/or the hydrophobic recovery of the low surface energy silicone. Herein, dynamic covalent crosslinking of a Schiff base-crosslinked silicone elastomer (PDMS

Indexed as

Biocompatible MaterialsBlood CoagulationSiliconesAnimalsDimethylpolysiloxanesFibrosisHumansHydrophobic and Hydrophilic InteractionsMaterials TestingMethacrylatesPolyethylene GlycolsSilicone ElastomersbaysilonBiocompatible MaterialsDimethylpolysiloxanesMethacrylatesPolyethylene GlycolsSilicone ElastomersSiliconesanti‐fibroticanti‐foulingdynamic covalent chemistryhydrophilicitypolydimethylsiloxaneSchiff base crosslinkingsilicone rubber

Identifiers

PMID42206408
PMCPMC13307658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.