Evidence map›Paper›PMID 42206280›Full record

ArticleNPJ dementia2026

Early onset rapidly progressive frontotemporal dementia due to a novel MAPT P301A variant with functional validation of pathogenicity.

Kiet Hua, Maryam R Pearson, Brandon I Apresa, Jesseca M Chung, Andrew J Ambrose, Susan M Hiatt, Argentina Lario Lago, Matthew Gh Hall, Liya Rabkina, Stephanie Kwan and 13 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Kiet HuaEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Maryam R PearsonDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA USA.
Brandon I ApresaDepartment of Neurology, University of California, San Francisco, San Francisco, CA USA.
Jesseca M ChungDepartment of Neurology, University of California, San Francisco, San Francisco, CA USA.
Andrew J AmbroseDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA USA.
Susan M HiattHudsonAlpha Institute for Biotechnology, Huntsville, AL USA.
Argentina Lario LagoEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Matthew Gh HallEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Liya RabkinaEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Stephanie KwanEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Joyce DoEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Iyas DaghlasDepartment of Neurology, University of California, San Francisco, San Francisco, CA USA.
Annie McDonoughDepartment of Neurology, University of California, San Francisco, San Francisco, CA USA.
Elan L GutermanDepartment of Neurology, University of California, San Francisco, San Francisco, CA USA.
Denise J XuDepartment of Neurology, University of California, San Francisco, San Francisco, CA USA.
Howard J RosenEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Jane GrimwoodHudsonAlpha Institute for Biotechnology, Huntsville, AL USA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, AL USA.
Michelle R ArkinDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA USA.
Adam L BoxerEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Jennifer S YokoyamaEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Peter A LjubenkovEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.
Brandon B HolmesEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frontotemporal dementia represents a group of clinical syndromes characterized by progressive changes in behavior or language that are associated with frontotemporal lobe atrophy. Around 40% of FTD cases are familial, with mutations in

Indexed as

DiseasesGeneticsNeurologyNeuroscience

Identifiers

PMID42206280
PMCPMC13201157

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.