ArticleBeilstein journal of nanotechnology2026
Molecular engineering of individual dye-based nanoparticle photostability for ultrabright two-photon fluorescence.
Article in Beilstein journal of nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dye-based fluorescent organic nanoparticles (dFONs) represent a promising class of bioimaging probes combining high brightness with molecular tunability. While their fluorescence performance is well established for one-photon excitation, their single-particle properties under two-photon excitation remain to be evaluated. Here, we perform a comprehensive optical characterization of two distinct dFONs designed to exhibit the same two-photon brightness but with different photostabilities. Saturation measurements of individual nanoparticles allowed for an estimation of their two-photon absorption cross sections, which were found to be consistent with ensemble values when taking into account a local-field correction. Time-resolved experiments further revealed that nanoparticles with the highest absorption cross section photobleach significantly faster, confirming the trade-off between absorption efficiency and photostability. These results demonstrate that the photophysical behavior of dFONs can be rationally engineered at the molecular level and provide design principles for the development of optimized organic nanoparticles for nonlinear fluorescence microscopy and bioimaging applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.