Health actions after direct-to-consumer genetic testing for medically actionable conditions.

Purpose: Millions of individuals have undergone direct-to-consumer genetic testing (DTC-GT), which can include results for medically actionable conditions. We sought to determine whether individuals with DTC-GT results for medically actionable cancer and cardiovascular conditions take health actions, such as sharing results with health care professionals (HCPs) and following subsequent recommendations to reduce health risks. Methods: We conducted a retrospective survey study of 23andMe research participants aged ≥18 years who were positive for variant(s) in Results: Among 1076 survey respondents, most were female (72.3%) and self-reported White or European (85.5%), and average age was 56.8 years (SD 16.0). In total, 67.7% reported a personal and/or family history relevant to their 23andMe-identified variant, and 81.9% had not had prior genetic testing for the variant; 72.9% of the results were shared with biological relatives; and 46.1% of results were shared with HCPs, with result sharing being highest for Conclusion: Most individuals receiving medically actionable results through DTC-GT had no prior knowledge of their genetic health risks, despite many reporting a relevant personal and/or family history. When individuals shared results with HCPs and received medical recommendations, adherence was high.