ArticleJournal of maxillofacial and oral surgery2026
Evaluation of the Osteogenic Potential of Periodontal Ligament and Tooth-Derived Substrates Effect on Osteogenesis: An In Vitro Pilot Study.
Article in Journal of maxillofacial and oral surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model.Journal of functional biomaterials · 2024Article
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Authors and funding
8 authors.
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Abstract
Objective: The goal of this in vitro pilot study was to compare the osteogenic potential of different ground human tooth preparations. Methods: Twelve maxillary third molars were included and divided into four groups: FT (full tooth), containing all dental tissues (enamel, dentin, pulp, cementum, and periodontal ligament); WE, without enamel; WPL, without periodontal ligament; and WEPL, without enamel and periodontal ligament. The teeth were ground to macroscopically homogeneous particles. The new bone formation was the primary variable evaluated. Pre-osteoblastic cells were incubated with protein extracted from this substrate to verify their osteoinductive potential. Cell proliferation, viability assays, mRNA expression of type I Collagen (COL-I), RUNX-2, BMP-2, and mineral nodules were assessed to achieve the main outcome. Data were analyzed using two-way ANOVA and Tukey tests, considering alpha = 5%. Results: The FT group had the lowest proliferation cell rates, whereas WEPL had the highest rates ( Conclusion: The dental substrate without enamel and periodontal ligament (WEPL) showed better and improved results than the other groups, revealing promising osteogenic potential for use as a biomaterial for grafting.
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