Evidence map›Paper›PMID 42206123›Full record

ArticleJournal of maxillofacial and oral surgery2026

Improvement in Survival Rates and Quality of Life Among Patients Surgically Treated for Squamous Cell Carcinoma of the Oral Cavity.

Giancarlo Tirelli, Enrico Zanelli, Jerry Polesel, Nicoletta Gardenal, Vittorio Ramella, Chiara Mineo, Simone Zucchini, Marco Piovesana, Vittorio Grill, Fabiola Giudici and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of maxillofacial and oral surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giancarlo TirelliDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Enrico ZanelliDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy.
Nicoletta GardenalDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Vittorio RamellaDepartment of Medical, Surgical and Health Sciences, Section of Plastic Surgery, University of Trieste, Trieste, Italy.
Chiara MineoDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Simone ZucchiniDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Marco PiovesanaDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Vittorio GrillDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Fabiola GiudiciUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy.
Francesca Boscolo NataDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Alberto MarcuzzoDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.
Paolo Boscolo-RizzoDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada Di Fiume, 447, 34149 Trieste, Italy.ORCID 0000-0002-4635-7959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The study aimed to assess if outcomes for oral squamous cell carcinoma (OSCC) patients have improved, and if so, whether these improvements correlate with changes in diagnostic and therapeutic methods over time. Methods: Retrospective study including patients surgically treated for OSCC between 2002 and 2020. Results: Among the 193 consecutive patients with primary OSCC who met the inclusion criteria (median age 66; 60.4% male), 80 (41.4%) were treated between 2002 and 2011, and 113 (58.6%) between 2011 and 2020. Multivariate analysis showed a significant improvement in overall survival rates from 2012 to 2020, compared with the period from 2002 to 2011 (HR for death, 0.33; 95% CI 0.17-0.67). Similar observations have emerged in progression-free and disease-specific survival. When stratified by stage, the improvement was found to be significant only for advanced stages. The use of NBI during both preoperative and operative setting as well as margin mapping significantly increased over the time. Both patients with early and advanced-stage OSCC treated between 2012 and 2020 exhibited improved pain scores. Conclusions: Despite the shift to less invasive surgeries, our analysis shows significant improvement over time, especially in advanced-stage diseases, highlighting the impact of evolving strategies on challenging cases.

Indexed as

Margin mappingNarrow band imagingOral cavity cancerSquamous cell carcinomaSurgerySurvival

Identifiers

PMID42206123
PMCPMC13201822

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.