ArticleFrontiers in nutrition2026
Association of the sarcopenia index with incident depressive symptoms and adverse depressive symptom trajectories.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The sarcopenia index (SI) is an accessible marker associated with muscle health, with cross-sectional link to depression has been reported. However, longitudinal evidence between baseline SI and future depressive symptoms is limited, without investigations on heterogeneous symptom trajectories. We intended to figure out the correlation of baseline SI and both the incidence of depressive symptoms and membership in distinct depressive symptom trajectories. Methods: Utilizing data from the Health and Retirement Study (2016-2022), our cohort included 6,286 participants free of depressive symptoms at baseline for the incident analysis and 5,699 for the trajectory analysis. Distinct symptom patterns were identified using group-based trajectory modeling (GBTM) across four waves. Associations were determined using Cox proportional hazards regression for incident depressive symptoms and multinomial logistic regression for trajectory membership. Results: Over the 6-year follow-up, 1,311 participants developed depressive symptoms (incidence rate: 47.73 per 1,000 person-years). Each standard deviation (SD) increase in baseline SI was connected to decreased likelihood of incident depressive symptoms (Hazard Ratio [HR] = 0.91; 95% Confidence Interval [CI]: 0.85-0.98; Conclusion: Consistent association was observed between a higher baseline sarcopenia index and both a lower likelihood of incident depressive symptoms and a lower risk of membership in adverse symptom trajectories in older adults. These findings highlighted the utility of SI on identifying individuals at elevated risk for unfavorable long-term depressive symptom progression among older population.
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