ArticleFrontiers in immunology2026
Age-related and disease-specific changes in B-cell profiles in older adults with immune thrombocytopenia.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Immune thrombocytopenia is an autoimmune bleeding disorder that is more prevalent among older adults. Ageing itself reduces B-cell counts, a change also observed in patients with ITP. This study examined the B cell profiles of patients with ITP aged over 65 (ITP>65) and aged 65 or under (ITP ≤ 65). These ITP groups were compared with age-matched healthy controls to determine whether the observed differences were due to the disease itself or the effects of ageing. Methods: Blood samples were processed and stained using the EuroFlow 8-colour PIDOT and pre-germinal centre B-cell tubes, following the EuroFlow SOPs for staining cell surface membrane markers. Results: Patients with ITP>65, compared with those ≤65, showed reduced immature/transitional B cell subsets, an increased population of CD21-CD24- naïve B cells, and higher plasma B-cell activating factor levels. Comparison of the ITP ≤ 65 group with the HC ≤ 65 group showed that patients with ITP had a lower B-cell count, but a significant increase in the CD21-CD24- naïve B-cell subset. Patients with ITP>65 had expanded CD21-CD24- and CD21-CD24++ naïve and memory IgMD+ B-cell populations compared to Conclusion: These findings suggest that ageing induces modifications to the B-cell phenotype that are similar to those observed in patients with ITP, except for the expansion of the CD21-CD24- naïve B-cell subset,
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