ArticleERJ open research2026
e-Lung computed tomography biomarkers are associated with outcomes in fibrotic interstitial lung diseases.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Automated identification of interstitial lung abnormalities in lung screening using quantitative CT.BMJ open respiratory research · 2026Article
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The e-Lung weighted reticulovascular score (WRVS) is an automated computed tomography biomarker that quantifies interstitial lung disease (ILD) severity and is associated with prognosis in patients with idiopathic pulmonary fibrosis (IPF). The aims of the present study were to evaluate WRVS as a prognostic factor in patients with non-IPF ILD. Methods: The test cohort comprised patients from the Open Source Imaging Consortium and the validation cohort, patients recruited to the prospective German CoWorker ILD registry. Associations between baseline and serial WRVS with future forced vital capacity (FVC) decline and survival were tested. Results: Median survival was 7.1 and 6.1 years in the test (n=302) and validation (n=378) cohorts, respectively. Baseline WRVS was associated with mortality in test (hazard ratio (HR) 1.11, 95% CI 1.08-1.14; p<0.001, C-index 0.75) and validation (HR 1.12, 95% CI 1.09-1.15; p<0.001, C-index 0.72) cohorts. A threshold WRVS of ≥15% was associated with mortality in both cohorts (HR 4.77, 95% CI 3.11-7.31; p<0.001, C-index 0.71, and HR 3.49, 95% CI 2.48-4.91; p<0.001, C-index 0.63 for test and validation cohorts, respectively). After adjustment for FVC, age and sex, baseline WRVS was associated with future FVC decline or death in test (OR 1.13, 95% CI 1.06-1.21; p<0.001, C-index 0.72) and validation (OR 1.18, 95% CI 1.11-1.25; p<0.001, C-index 0.72) cohorts. A rise in WRVS of 3% on serial computed tomography was associated with mortality in both test (HR 5.69, 95% CI 2.77-11.70; p<0.001, C-index 0.75) and validation cohorts (HR 1.99, 95% CI 1.09-3.65; p=0.026, C-index 0.57). Conclusion: In patients with non-IPF ILD, the e-Lung WRVS biomarker is associated with mortality and FVC decline when applied to baseline high-resolution computed tomography scans replicating previous studies in IPF. Patients with an increase in WRVS of 3% on serial computed tomography scans have significantly increased risk of mortality.
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