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ArticleTobacco induced diseases2026

Acceptance and preferences for different nicotine substitute products to reduce tobacco smoking in people living with HIV: Results from an internal pilot study of a randomized trial.

Christof M Schönenberger, Stephanie Campos Ochoa, Benjamin Speich, David Hans-Ulrich Haerry, Ellen Cart-Richter, David Jackson-Perry, Alissa Hutter, Loan Panettieri, Samuel Aggeler, Sandra E Chaudron and 18 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco induced diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06789692 (Reduce Tobacco Use in People Living With HIV in Switzerland), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06789692 narecruitingnot on this map

Reduce Tobacco Use in People Living With HIV in Switzerland: A Pragmatic Randomized Trial Within the Swiss HIV Cohort Study

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2025 to 2027Enrolled972ConditionsHIV, SmokingArmstobacco smoking substitution products
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Christof M SchönenbergerDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Stephanie Campos OchoaDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Benjamin SpeichDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
David Hans-Ulrich HaerryRETUNE-HIV Participant Advisory Board and Patient Organization 'Positive Council', Bern, Switzerland.
Ellen Cart-RichterRETUNE-HIV Participant Advisory Board and Lausanne HIV-Community Council, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
David Jackson-PerryRETUNE-HIV Participant Advisory Board and Infectious Diseases Service, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
Alissa HutterDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Loan PanettieriDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Samuel AggelerDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Sandra E ChaudronDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Alexandra CalmyHIV Unit, Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
Matthias CavassiniDivision of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
Irene A AbelaDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Katharina KusejkoDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Huldrych F GünthardDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Johannes NemethDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Andri RauchDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Gilles WandelerDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Patrick SchmidDivision of Infectious Diseases, Infection Prevention and Travel Medicine, HOCH Health Ostschweiz, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Tamara DörrDivision of Infectious Diseases, Infection Prevention and Travel Medicine, HOCH Health Ostschweiz, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Bernard SurialDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Aurélie BerthetCenter for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Reto AuerCenter for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Marcel P StoeckleDivision of Infectious Diseases, University Hospital Basel, University of Basel, Basel, Switzerland.
Niklaus LabhardtDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Frédérique ChammartinDivision of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Matthias Briel *Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Alain Amstutz *Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTobacco smoking is an insufficiently addressed health burden among people living with HIV. The

methodsRETUNE is a pragmatic, randomized, multicenter trial using the 'Trials within Cohorts' (TwiCs) design embedded in the Swiss HIV Cohort Study. Participants are people living with HIV who are part of the cohort and smoke. Following the TwiCs design, participants can accept one of the offered intervention products or refuse all of them, after being randomized to the intervention group. This internal pilot study included the first 200 RETUNE participants randomized between February and September 2025. We report the acceptance rate and participants' experiences with the intervention products, based on trial data and additional questionnaires.

resultsOf the 98 participants randomized to the intervention group, 53 accepted a nicotine substitute product while 45 declined the intervention. The majority chose e-cigarettes (31/53; 59%), one-third chose nicotine patches (17/53; 32%), and four participants chose nicotine pouches (4/53; 8%). The most common reason for declining all offered products was no interest in quitting tobacco smoking (34/53; 64%). Overall, 37/53 (70%) intervention participants completed the pilot study survey. Most (27/37; 73%) continued the initially chosen product; the remaining changed the product, the nicotine concentration, or the flavor; however, no one stopped the smoking cessation intervention entirely.

conclusionsThe results of this internal pilot support the feasibility of the RETUNE trial. The observed acceptance rate was similar to our estimate. E-cigarettes were the preferred product. We are continuing recruitment for the RETUNE trial. CLINICAL

trial registrationThe study is registered on the official website of ClinicalTrials.gov. IDENTIFIER: NCT06789692.

Indexed as

e-cigarettesHIVnicotine pouchessmoking cessationTwiCs

Identifiers

PMID42205972
PMCPMC13205642

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.