ArticleCancer management and research2026
Clinical Efficacy and Security Analysis of CDK4/6 Inhibitors Combined with ET in Patients with HR
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the clinical efficacy and security of CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) in patients with hormone receptor-positive (HR⁺), human epidermal growth factor receptor 2-negative (HER2 Methods: We selected 145 patients with HR Results: The ORR was significantly higher in the observation group (CDK4/6i + ET) compared to the comparison group (ET alone) (45.8% vs. 22.6%, p=0.005). The DCR was also superior in the observation group (84.3% vs. 67.7%, p=0.018). The median PFS was 15.0 months (95% CI: 12.5-17.5) in the observation group versus 9.0 months (95% CI: 7.5-10.5) in the comparison group (p<0.001). The median OS was 20.5 months (95% CI: 18.0-23.0) and 9.5 months (95% CI: 8.0-11.0), respectively (p=0.002). COX multivariate analysis identified ER level as an independent protective factor (HR=0.559, 95% CI: 0.352-0.888, p<0.05), while liver metastasis was an independent risk factor for PFS. Conclusion: CDK4/6 inhibitors combined with ET demonstrates favorable clinical efficacy in patients with HR⁺HER2
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.