Evidence map›Paper›PMID 42205861›Full record

ArticleInfection prevention in practice2026

Prophylactic incisional wound irrigation with aqueous chlorhexidine gluconate vs aqueous povidone iodine for prevention of surgical site infection in elective abdominal surgery.

Nathan Bontekoning, Hannah Groenen, Gerjon Hannink, Markus W Hollmann, Stijn W de Jonge, Niels Wolfhagen, Marja A Boermeester, EPO2CH Study Group, EPOCH Study Group

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In one paragraph

Article in Infection prevention in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nathan BontekoningAmsterdam UMC Location University of Amsterdam, Department of Surgery, Meibergdreef 9, Amsterdam, The Netherlands.
Hannah GroenenAmsterdam UMC Location University of Amsterdam, Department of Surgery, Meibergdreef 9, Amsterdam, The Netherlands.
Gerjon HanninkDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Markus W HollmannAmsterdam UMC Location University of Amsterdam, Department of Anesthesiology, Meibergdreef 9, Amsterdam, The Netherlands.
Stijn W de JongeAmsterdam UMC Location University of Amsterdam, Department of Surgery, Meibergdreef 9, Amsterdam, The Netherlands.
Niels WolfhagenAmsterdam UMC Location University of Amsterdam, Department of Surgery, Meibergdreef 9, Amsterdam, The Netherlands.
Marja A BoermeesterAmsterdam UMC Location University of Amsterdam, Department of Surgery, Meibergdreef 9, Amsterdam, The Netherlands.
EPO2CH Study Group
EPOCH Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Incisional prophylactic intra-operative wound irrigation (pIOWI) with an aqueous antiseptic solution effectively reduces surgical site infections (SSIs); however, data on the use of aqueous chlorhexidine gluconate remain limited, and no clinical comparisons with aqueous povidone iodine exist. We therefore compare the efficacy of aqueous chlorhexidine gluconate with aqueous povidone iodine for incisional pIOWI in the prevention SSI in elective abdominal surgery. Methods: A post hoc analysis of data from the randomised controlled Enhanced PeriOperative Care and Health (EPO Findings: Weighted regression analysis showed a statistically non-significant difference in the SSI rate (-3.03%, 95% confidence interval [CI]: -7.04 to 0.98) for pIOWI with aqueous chlorhexidine gluconate (4.05%) vs aqueous povidone iodine (7.08%). Interpretation: While the SSI rate for pIOWI with aqueous chlorhexidine gluconate showed a lower estimated SSI incidence than with aqueous povidone iodine, the difference was not statistically significant, with wide CIs, indicating uncertainty. Further research is needed to assess the hypothesis that pIOWI with chlorhexidine gluconate, than in povidone iodine, may reduce SSI.

Indexed as

Chlorhexidine gluconatePovidone iodineSurgical site infectionWound irrigation

Identifiers

PMID42205861
PMCPMC13208083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.