Evidence map›Paper›PMID 42205855›Full record

ReviewInternational journal of particle therapy2026

Emerging Outcome Trends From Proton Therapy for Pediatric CNS Tumors: A Systematic Review.

Jasper Greenland, Jake Kendrick, Martin A Ebert, Milad Mirzaei, Rohen White, Joshua Dass, Adriano Polpo, Pejman Rowshanfarzad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of particle therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jasper GreenlandSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, Western Australia, Australia.
Jake KendrickSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, Western Australia, Australia.
Martin A EbertSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, Western Australia, Australia.
Milad MirzaeiSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, Western Australia, Australia.
Rohen WhiteDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Joshua DassDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Adriano PolpoSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, Western Australia, Australia.
Pejman RowshanfarzadSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, Western Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This systematic review aims to provide a summary of outcomes of pediatric brain tumor patients treated with proton therapy (PT). Outcomes focused on include long-term efficacy and late toxicities. This study provides an analysis of survival, disease control, and safety outcomes across major pediatric brain tumor histologies to support contemporary clinical decision-making. Methods: A literature search was conducted across PubMed, Scopus, and Web of Science to identify studies reporting overall survival (OS), progression-free survival (PFS), local control (LC), or late toxicity in patients under 21 years with brain tumors treated with PT. Weighted linear regression was performed on survival outcomes modeling trends over post-treatment follow-up. Safety outcomes were qualitatively assessed based on histology and pooled where possible to facilitate cross-study comparison. Results: Seventy-seven studies were included, with 40 reporting on OS following PT in a total of 3798 patients. Statistically significant time-dependent models were obtained for medulloblastoma (PFS: Conclusion: Statistically significant trends in medulloblastoma, ependymoma, and BOS chordoma were identified, along with consistent outcomes in LGG and craniopharyngioma outcomes. Together, these findings provide clinicians with clearer expectations of prognosis following PT and establish reference benchmarks that can inform treatment planning, counsel families, and serve as a comparative foundation for future clinical research.

Indexed as

Brain tumorsPediatric cancerProton therapySystematic review

Identifiers

PMID42205855
PMCPMC13202250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.