ArticleFrontiers in medicine2026
Oral microbiota alterations in radiographic axial spondyloarthritis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Objective: To investigate alterations in the oral microbiome of patients with radiographic axial spondyloarthritis (r-axSpA), to identify microbial taxa associated with disease status and structural progression, and to explore potential links between oral microbiota composition and systemic immunological profiles. Methods: An observational cross-sectional study was conducted including 57 radiographic axial spondyloarthritis patients and 41 healthy controls. Oral samples were analyzed using 16S rRNA gene sequencing; amplicon sequence variants (ASVs) were generated using LotuS2/DADA2 and taxonomically annotated with SILVA, Greengenes, and HITdb. Alpha and beta diversity were assessed using ACE, Pielou indexes, and UniFrac distances with PERMANOVA and ANOSIM. Differential abundance was determined via LEfSe (LDA > 2, Results: R-axSpA patients showed alterations in oral microbiome composition compared with controls, although alpha diversity remained largely comparable. Actinobacteria, Spirochaetes, and Synergistetes tended to be enriched in r-axSpA patients, mainly driven by an increased abundance of Conclusion: Patients may exhibit a distinct proinflammatory oral microbiome profile, with increased representation of
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