QDPR rs3733570 polymorphism is associated with type 2 diabetes and diabetic kidney disease accompanied by hyperlipidemia in the Chinese Han population.

Minda Dong, Yeqiang Liu, Zhijie Pu, Hong Shen, Zhiguo Li

Abstract read

In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minda DongThe Hebei Key Lab for Organ Fibrosis, School of Public Health, International Science and Technology Cooperation Base of Geriatric Medicine, North China University of Science and Technology, Tangshan, China.

Yeqiang LiuDepartment of Endocrinology, Tangshan Central Hospital, Tangshan, China.

Zhijie PuDepartment of Endocrinology, Yutian County Hospital, Tangshan, China.

Hong ShenModern Technology and Educational Center, North China University of Science and Technology, Tangshan, China.

Zhiguo LiThe Hebei Key Lab for Organ Fibrosis, School of Public Health, International Science and Technology Cooperation Base of Geriatric Medicine, North China University of Science and Technology, Tangshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Genetic factors play important roles in the development of type 2 diabetes mellitus and its complications. Diabetic kidney disease, a common microangiopathic complication of diabetes, is linked to an increased risk of major cardiovascular events and overall mortality. Tetrahydrobiopterin deficiency is implicated in DKD pathogenesis, and the Methods: Genetic analysis for SNPs in the coding region was conducted using a systematic screening approach. Direct sequencing and statistical analysis tools were employed to identify potentially functional SNPs. Following this, rs3733570 was selected based on its potential biological relevance and frequency in the target population. A total of 1,844 participants from Kai Luan General Hospital (Tangshan, China) were included for validation. Genotyping of Results: Regression analysis showed that the rs3733570 AA genotype was associated with increased risk of T2DM (OR = 1.33, 95% CI: 0.99-1.79, Conclusion: The

Indexed as

diabetic kidney diseaseQDPRsingle nucleotide polymorphismstratified analysestype 2 diabetes mellitus

Identifiers

PMID42205834

DOI10.3389/fmed.2026.1811028

PMCPMC13201145

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.