Evidence map›Paper›PMID 42205822›Full record

ArticleFrontiers in medicine2026

Comparison of the efficacy of subthreshold micropulse laser versus intravitreal anti-VEGF therapy for chronic central serous chorioretinopathy.

Jinyu Li, Tiepei Zhu, Yanan Zhu, Yao Wang, Haixiu Wu, Zhiqing Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinyu LiEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.
Tiepei ZhuEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.
Yanan ZhuEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.
Yao WangEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.
Haixiu WuEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.
Zhiqing ChenEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To compare the therapeutic ability between 577-nm subthreshold micropulse laser (SML) and intravitreal anti-VEGF injection (IVA) in the treatment of chronic central serous chorioretinopathy (cCSCR). Methods: The medical records of 50 cCSCR patients (50 eyes) who underwent SML (30 eyes) or IVA injection (20 eyes) were reviewed in this retrospective cohort study. Changes in best-corrected visual acuity (BCVA), central retinal thickness (CRT), subretinal fluid (SRF), and subfoveal choroidal thickness (SFCT) measured by optical coherence tomography (OCT) at baseline, 1, 3, and 6 months post-treatment were extracted and compared between the two groups. Results: Baseline demographic and clinical characteristics, including age, sex, leakage pattern on fluorescein angiography (FA), BCVA, CRT, SRF, and SFCT, were comparable between the two groups (all Conclusion: Both SML and anti-VEGF has been confirmed effective in improving visual acuity and achieving anatomical recovery in patients with cCSCR. At 6 months, IVA was associated with greater reduction in SFCT, whereas SML achieved superior SRF resolution. These findings support individualized treatment selection based on disease characteristics and underlying pathophysiology.

Indexed as

chronic central serous chorioretinopathy (cCSCR)intravitreal anti-VEGF injection (IVA)subfoveal choroidal thickness (SFCT)subretinal fluid (SRF)subthreshold micropulse laser (SML)

Identifiers

PMID42205822
PMCPMC13203991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.