ArticleChemical science2026
Substrate-driven iridium photocatalysts enable diastereoselective dearomative polyoxygenation of hydroxyquinolines.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a novel strategy for the direct, diastereoselective dearomative polyoxygenation of 8-hydroxyquinolines, leveraging a substrate-coordinated Ir(iii) complex as a self-activating photocatalyst under visible light and atmospheric oxygen. In this system, the hydroxyquinoline substrate coordinates to the Ir precatalyst generating an Ir-oxyquinolate complex. This species activates the substrate and acts as a photosensitizer, promoting the generation of singlet oxygen and enabling the formation of multiple C-O bonds in a single step with excellent regio- and stereocontrol. Mechanistic investigations, including ligand exchange experiments, control reactions, and DFT studies, reveal that the reaction proceeds
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