Evidence map›Paper›PMID 42205699›Full record

ArticleiScience2026

PIP4K2A/2B inhibitor suppresses tumor growth in a xenograft model of NSCLC.

Zunyu He, Song Chen, Marcus Bosenberg, Viswanathan Muthusamy, Yibo Xi, He Wang, Fabrizio Micheli, Agostino Cianciulli, Claudia Beato, Michael Van Zandt and 2 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zunyu HeDepartment of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Song ChenDepartment of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Marcus BosenbergYale Center for Precision Cancer Modeling, Yale School of Medicine, New Haven, CT 06520, USA.
Viswanathan MuthusamyYale Center for Precision Cancer Modeling, Yale School of Medicine, New Haven, CT 06520, USA.
Yibo XiDepartment of Laboratory Medicine and Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
He WangDepartment of Laboratory Medicine and Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Fabrizio MicheliAptuit Srl, an Evotec Company, Via Fleming 4, 37135 Verona, Italy.
Agostino CianciulliAptuit Srl, an Evotec Company, Via Fleming 4, 37135 Verona, Italy.
Claudia BeatoAptuit Srl, an Evotec Company, Via Fleming 4, 37135 Verona, Italy.
Michael Van ZandtNew England Discovery Partners, Branford, CT 06405, USA.
Jonathan EllmanDepartment of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Ya HaDepartment of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.

Funding

Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiryR35GM122473 · NIGMS · YALE UNIVERSITY · PI JONATHAN A ELLMAN · 2017 to 2026
$7.6M
The biochemical mechanism and pharmacological inhibition of phosphatidylinositol phosphate kinasesR01GM150502 · NIGMS · YALE UNIVERSITY · PI YA HA · 2023 to 2026
$1.4M
NIGMS NIH HHS R01 GM150502NIGMS NIH HHS R35 GM122473
6 · The paper itself

Abstract

The PIP4K family of lipid kinases phosphorylates the rare phospholipid PI(5)P at the 4-position, generating PI(4,5)P

Indexed as

CancerPharmacology

Identifiers

PMID42205699
PMCPMC13206749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.