Evidence map›Paper›PMID 42205697›Full record

ArticleiScience2026

Ultra short waves alleviate ulcerative colitis via TRPV2 mediated-macrophage polarization.

Yao Ning, Yong Wang, Mengnan Guo, Jiangxu Mai, Wei Sun, Zheng Ge, Ke Han, Chao Wang, Qin Li, Xia Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yao NingDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Yong WangDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Mengnan GuoDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Jiangxu MaiDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Wei SunDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Zheng GeDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Ke HanDepartment of Rehabilitation, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250012, China.
Chao WangDepartment of Rehabilitation, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250012, China.
Qin LiDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Xia WangDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Jingxin LiDepartment of Physiology, School of Basic Medical Sciences, Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultra short wave (USW) therapy, known for its deep tissue penetration in electromagnetic waves, is clinically used to treat local inflammation and alleviate pain, yet its role in intestinal inflammation via macrophage regulation remains unclear. We investigated whether USW exerts non-thermal effects on macrophages to alleviate colitis using dextran sulfate sodium (DSS)-induced mouse models and LPS-stimulated BMDMs/THP-1 cells. Results demonstrated that USW significantly ameliorated intestinal inflammation by directly targeting macrophages, as macrophage depletion completely abrogated its therapeutic effects. Mechanistically, USW induced distinct shifts in intracellular calcium flux and modulated cytokine expression through the TRPV2/CaMKII/Nrf2 signaling pathway. This study confirms that USW alleviates colitis by regulating macrophage polarization and calcium signaling, uncovering a distinct therapeutic pathway and highlighting the potential of non-invasive USW treatment as an effective strategy for improving colitis prognosis.

Indexed as

Biological sciencesGastroenterologyImmunology

Identifiers

PMID42205697
PMCPMC13206742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.